Leopard print—or animal prints in general, which range from zebra, python, cow, and many that do not really exist—has always been with us since the early days when wearing the skins of the beasts killed for food began. Its purposes as meaning have variously evolved. One cannot say that some do not exist. Distaste for fur commoditization would not keep anyone from the urge to wear it. The jungle may be ruled by a lion, but when it comes to fashion, the leopard, or rather the leopard's spots, would be royalty. Michael Kors might be the one to refer to this as 'an extreme neutral'.
For many centuries, wearing a leopard's skin was associated with status and aristocracy, with illustrations of indoors depicted with Sheshat, the Egyptian god of reason in exotic leopard skin, and the Greek god of wine, loving clothes sinners wearing leopard's skin among Dionysus and Zulu rulers in the nineteenth century.
Following this: In 2013, the world of adventures in Surrey, England, stopped visitors wearing leopard and tiger prints because they felt it was somewhere inappropriate for dizzy patrons, who saw them either as a meal or potential, err, playmates.
Be sure to add, however, the book "Fierce: the History of Leopard Print," which will be published in 2018. Draw the line that although there is a world of animal prints in the fashion world, a leopard-printed wardrobe can quickly become tacky.